Portobelo: This historic town on the Caribbean coast was once a crucial port during the Spanish colonial era. Visitors can explore the San Felipe Fortress and Portobelo National Park, as well as the colorful local Afro-Caribbean culture. The annual Black Christ Festival is a major religious event in the region.

Fort San Lorenzo: A lesser known but impressive site, the San Lorenzo Fortress stands at the mouth of the Chagres River. Built by the Spanish in the 16th century, it played a key role in defending the region from pirates. The fort offers sweeping views of the Caribbean Sea and surrounding jungle.