Darién National Park: This UNESCO World Heritage Site is one of the most biodiverse regions in the world. The park offers rugged, untouched wilderness with opportunities to see rare wildlife like jaguars, harpy eagles, and tapirs. Visitors can also explore the rivers and mangroves of the Bayano Caves.

Yaviza: The endpoint of the Pan-American Highway, Yaviza is the gateway to the Darién Gap, one of the most remote and challenging areas to explore in Panama. The town is an excellent base for those looking to venture into the jungle and experience the indigenous Emberá culture.